Soft Tissue Pathology
    ZM93 Monospecific Mouse Monoclonal

    Key players in the Notch pathway are the TLE genes, which are human homologs of the Drosophila Groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. Transducin-like enhancer protein 1 (TLE1) is a protein that is encoded by the TLE1 gene and is involved in control of hematopoiesis, neuronal, and terminal epithelial differentiation. Positive immunohistochemical nuclear staining with anti-TLE-1 has been shown to be a useful addition to an IHC panel when differentiating synovial sarcoma from other soft tissue malignancies.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Synovial sarcoma
    Isotype:IgG2a /κ
    Immunogen:Recombinant human TLE1 fragment (aa 175-338)
    Ordering Information
    Classification IVD
    Catalogue Number Z2403ML
    Classification IVD
    Catalogue Number Z2403ML
    Package Inserts
    IFU-TLE1 ZM93
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.