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    Thymidylate Synthase (TS)

    General & Epithelial Markers
    ZR245 Rabbit Monoclonal

    It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), essential for DNA biosynthesis. TS is also a critical target for fluoropyrimidines, an essential antineoplastic drug widely used to treat solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP, which inactivates TS by forming a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:5-FU resistant cancer
    Immunogen:Recombinant human thymidylate synthase protein fragment (around aa 60-174) (exact sequence is proprietary)
    Ordering Information
    Classification IVD
    Catalogue Number Z2719RL
    Classification IVD
    Catalogue Number Z2719RL
    Package Inserts
    IFU-Thymidylate Synthase (TS) ZR245
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.