Preferred Clone

Human adrenal gland stained with anti-SF-1 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of cortical cells.

Steroidogenic Factor-1 (SF-1)

Neuropathology/Endocrine

ZR350 Rabbit Monoclonal

The Steroidogenic Factor 1 (SF-1) protein is a transcription factor involved in sex determination by controlling activity of genes related to the reproductive glands or gonads and adrenal glands. This protein is encoded by the NR5A1 gene, a member of the nuclear receptor subfamily, located on the long arm of chromosome 9 at position 33.3. SF-1 is expressed in the cortex of normal adrenal gland, adrenal cortical adenomas and carcinomas. It is also positive in sex-cord stromal tumors of testicle and ovarian origins.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Adrenal cortical carcinoma

Visualization:Nuclear

Isotype:IgG

Immunogen:Full-length of human SF-1 protein

Ordering Information

USA International

Package Inserts

IFU-Steroidogenic Factor-1 (SF-1) ZR350

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

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SDS