ZM101 Mouse Monoclonal

    Mantle cell lymphoma (MCL) accounts for 5% to 10% of mature B-cell neoplasms and is characterized by overexpression of cyclin D1 (bcl-1) protein due to the specific translocation t(11;14) (q13;q32). However, approximately 5%-10% of MCLs lack cyclin D1 expression and may be misdiagnosed by overreliance on cyclin D1 IHC. Recent studies showed that the strong nuclear expression SOX-11 was found in almost all cyclin D1-positive MCL (93%-100%) and cyclin D1-negative MCL (~100%). The nuclear expression of SOX-11 is highly associated with both cyclin D1-positive and negative MCL. SOX-11 IHC is of value in further defining pathologic features of CD5+ DLBCL. Routine use of anti-SOX-11 in cases of suspected CD5+ DLBCL might help identify additional cases of cyclin D1-negative blastoid MCL. SOX-11 can also be detected in some BL, LBL and T-PLL, although the different morphological and phenotypic features of these malignancies allow easy recognition of the cases of cyclin D1-negative MCL.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Mantle cell lymphoma
    Immunogen:Synthesized peptide from human SOX-11 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2606ML
    Classification IVD
    Catalogue Number Z2606ML
    Package Inserts
    IFU-SOX-11 ZM101
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.