Urinary Pathology
    ZR339 Rabbit Monoclonal

    Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a vital component of the citric acid cycle and the electron transport chain, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane. Many cancers are generally positive for SDHB, including renal cell carcinomas and gastrointestinal stromal tumors. A subset of RCC and GIST tumors associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Immunogen:Synthetic peptide corresponding to residues in human SDHB was used as an immunogen
    Ordering Information
    Classification IVD
    Catalogue Number Z2645RL
    Classification IVD
    Catalogue Number Z2645RL
    Package Inserts
    IFU-SDHB ZR339
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.