GI Pathology
    ZR167 Rabbit Monoclonal

    SATB2 is a DNA binding protein specifically binds nuclear matrix attachment regions. It is involved in transcription regulation and chromatin remodeling. SATB2 expression in colorectal carcinomas (CRC) is correlated with a good prognosis. In laryngeal squamous cell carcinoma, it functions as a tumor suppressor, wherein loss of expression is positively correlated with high tumor grade and recurrence. Moreover, SATB2, in combination with CK20, could identify almost all CRC’s. Upper gastrointestinal (GI) carcinomas and pancreatic ductal carcinomas are usually negative for SATB2, and ovarian carcinomas, lung adenocarcinomas, and adenocarcinomas from other origins are rarely positive SATB2. Additionally, SATB2 antibody can identify neuroendocrine neoplasms of the colon and rectum because SATB2 is usually negative in neuroendocrine neoplasms of the GI tract, pancreas, and lung. More recently, it has been reported that SATB2 is a sensitive marker for tumors with osteoblastic differentiation.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Colon or colon cancer
    Immunogen:Recombinant fragment (around aa150-350) of human SATB2 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2479RL
    Classification IVD
    Catalogue Number Z2479RL
    Package Inserts
    IFU-SATB2 ZR167
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.