Formalin-fixed and paraffin-embedded human head and neck small cell carcinoma stained with anti-RRM1 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of tumor cells

RRM1

General & Epithelial Markers

ZR114 Rabbit Monoclonal

Ribonucleotide reductase M1 polypeptide (RRM1) is one of two non-identical subunits for ribonucleoside-diphosphate reductase, an enzyme that catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated in quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer (NSCLC) to chemotherapy.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Breast or colon carcinoma

Visualization:cytoplasm

Isotype:IgG

Immunogen:Synthetic peptide corresponding to residues within aa700-800 of human RRM1

Ordering Information

USA International

Package Inserts

IFU-RRM1-ZR114- 0

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

Accept Reject

SDS