Lung/Mediastinum Pathology
    ZR400 Rabbit Monoclonal

    ROS1, an orphan receptor tyrosine kinase of the insulin receptor family, was initially identified as a homolog of v-ros from the UR2 sarcoma virus. ROS1 consists of a large extracellular domain composed of six fibronectin repeats, a transmembrane domain, and an intracellular kinase domain. While the function of ROS1 is undefined, it has been shown to play an essential role in the differentiation of epididymal epithelium. The first oncogenic fusion of ROS1, FIG-ROS1, was initially identified by research studies in glioblastoma. Investigators have found additional oncogenic ROS1 fusion proteins in NSCLC (at a frequency of ~1.6%), where the ROS1 kinase domain is fused to the amino-terminal region of a number of different proteins, including CD74 and SLC34A2.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Human brain, lung adenocarcinoma or primary glioblastoma
    Visualization:Cell surface
    Immunogen:Recombinant fragment corresponding to the cytoplasmic domain of human ROS1 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2756RL
    Classification IVD
    Catalogue Number Z2756RL
    Package Inserts
    IFU-ROS1-ZR400- 0
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.