Urinary Pathology
    66.4.C2 Mouse Monoclonal

    In normal kidney, gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman’s capsule adjoining the outgoing proximal tubule. Of other normal tissues examined, the gp200 is also localized along the luminal surfaces of breast lobules and ducts, the luminal surface of the epididymal tubular epithelium, within the cytoplasm of parathyroid parenchymal cells, and focally within the colloid of thyroid follicles. Thirty-one other normal tissues do not express similar or cross-reacting antigens. Reportedly, gp200 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas. 66.4.C2 may be a useful reagent in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Normal kidney or renal cell carcinoma
    Visualization:Membranous and cytoplasmic
    Isotype:IgG2a /κ
    Immunogen:Native from human renal cortical tissue homogenate
    Ordering Information
    Classification IVD
    Catalogue Number Z2256ML
    Classification IVD
    Catalogue Number Z2256ML
    Package Inserts
    IFU-RCC 66.4.C2
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.