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    Rb

    Soft Tissue Pathology
    G3-245 Mouse Monoclonal

    Members of the retinoblastoma (Rb) family, including the related proteins p107 and p130, share several properties, including the ability to regulate E2F dependent transcription and to regulate cell-cycle progression. The Rb gene product is a phosphoprotein that is expressed in most normal cells of vertebrates. Rb acts as a tumor suppressor by providing a cell cycle checkpoint between the G1 and S phases. The tumor suppressor gene RB1, encoding the retinoblastoma (Rb) protein, is located at 13q14. By immunohistochemistry, Rb1 expression is defect/negative in soft tissue tumors associated with 13q deletions, all spindle cell lipomas, pleomorphic lipomas, and cellular angiofibromas and most mammary-type myofibroblastomas. Rb1 expression is intact in histologic mimics.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Colon cancer
    Visualization:Nuclear
    Isotype:IgG1 /κ
    Immunogen:Human Rb aa 332-344
    Ordering Information
    Classification IVD
    Catalogue Number Z2553ML
    Classification IVD
    Catalogue Number Z2553ML
    Package Inserts
    IFU-Rb G3-245
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS