Urinary Pathology
    6H2.1 Mouse Monoclonal

    PTEN (phosphatase and tensin homolog deleted on chromosome ten) is a tumor suppressor gene that is mutated in a wide range of cancers. PTEN is located on chromosome sub-band 10q23.3 and encode a 403 amino acid protein which acts as a dual-specific protein and phospholipid phosphatase. As a lipid phosphatase, PTEN regulates phosphatidylinositol-3’-kinase by dephosphorylating the D3 position of phosphatidylinositol (3,4,5)-triphosphate and phosphatidylinositol (3,4)-biophosphate substrates, thereby antagonizing signal transduction downstream of phosphatidylinositol-(PI-3) kinase.7 Loss-of-function mutations in the PTEN gene lead to constitutive activation of multiple signaling pathways including the PI3K/Akt pathway which affects cell proliferation, apoptosis and migration. PTEN has also been shown to control p53 protein levels and transcriptional activity.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Prostate or prostate carcinoma
    Visualization:Cytoplasmic and nuclear
    Isotype:IgG2a /κ
    Immunogen:C-terminal 100 amino acids of PTEN
    Ordering Information
    Classification IVD
    Catalogue Number Z2077ML
    Classification IVD
    Catalogue Number Z2077ML
    Package Inserts
    IFU-PTEN 6H2.1
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.