Breast Pathology
    ZR290 Rabbit Monoclonal

    Progesterone is one of the central regulators of female reproduction. In breast development, progesterone is involved in the formation of lobular-alveolar structures and affects differentiation in the breast by modulation of milk protein synthesis. The cellular effects of progesterone are mediated through progesterone receptors (PR). PR, a protein with 946 amino acids, is a ligand-activated transcription factor member of the steroid receptor superfamily of nuclear receptors. PR is predominantly expressed in female sex steroid-responsive tissues such as the mammary gland, uterus, and ovary but is also found in other tissues such as endocrine cells of the Langerhans’ islets. The estrogen receptor (ER) and PR status have been used for over 20 years to predict breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Breast carcinomas
    Immunogen:Recombinant fragment (around aa 1-200) of human PGR (exact sequence is proprietary)
    Ordering Information
    Classification ASR
    Catalogue Number Z2728RL-A
    Classification IVD
    Catalogue Number Z2728RL
    Package Inserts
    IFU-PR ZR290 - IVD
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.