Preferred Clone

Human lymph node stained with anti-podoplannin antibody using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining of lymphatic endothelial cells..

Podoplanin

Lung/Mediastinum Pathology

ZM31 Monospecific Mouse Monoclonal

It recognizes a muco-protein of 38-43kDa, which is identified as Podoplanin (PDPN). It localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endothelium as well as lymphoangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Mesothelioma

Visualization:Cytoplasmic

Isotype:IgG1 /κ

Immunogen:Recombinant human Podoplanin (PDPN) protein fragment (around aa 24-126)

Ordering Information

USA International

Package Inserts

IFU-Podoplanin ZM31

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

Accept Reject

SDS