PD-1 (PDCD1)

    General & Epithelial Markers
    ZR408 Rabbit Monoclonal

    PDCD-1 (programmed cell death-1 protein), designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and valuable diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Lymph node
    Visualization:Cytoplasm & Membrane
    Immunogen:Recombinant fragment corresponding to extracellular domain of human PDCD1 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2764RL
    Classification IVD
    Catalogue Number Z2764RL
    Package Inserts
    IFU-PD-1 (PDCD1) ZR408
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.