Human lymph node stained with anti-PAX-5 antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear staining in B cells in follicle.

PAX-5

Hematopathology

ZM26 Monospecific Mouse Monoclonal

The PAX-5 gene is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding domain, known as the paired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. The PAX-5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis; therefore, PAX-5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Tonsil

Visualization:Nuclear

Isotype:IgG1 /κ

Immunogen:Recombinant human full-length PAX-5 protein

Ordering Information

USA International

Package Inserts

IFU-PAX-5 ZM26 - IVD0

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

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SDS