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    Gynecological Pathology
    KP10 Mouse Monoclonal

    p57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm’s tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors, including Wilms’ tumor, adrenocortical carcinoma, and rhabdomyosarcoma, display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Colon carcinoma or placenta
    Isotype:IgG2b /κ
    Immunogen:Recombinant human p57Kip2 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2173ML
    Classification IVD
    Catalogue Number Z2173ML
    Package Inserts
    IFU-p57Kip2 KP10
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.