Lung/Mediastinum Pathology
    ZR303 Rabbit Monoclonal

    p40 antibody (antibody recognizing ΔNp63 only) is an isoform of p63, is thought to function as a stem cell factor, responsible for maintaining cells in an uncommitted state with regenerative potential—a role that may be recapitulated in tumors derived from these cells. p40 is usually expressed in the basal or progenitor cell layer of stratified epithelia (e.g., squamous, urothelial, bronchial), basal cells of some glandular epithelia (e.g., prostate), and myoepithelial cells of breast and salivary glands, trophoblasts and thymic epithelial cells. In tumor tissues, p40 expression is specific for squamous cell carcinoma. p40 is equivalent to p63 in sensitivity for lung squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. p40 appears to be a more reliable marker for squamous cell carcinoma.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Lung squamous cell carcinoma
    Immunogen:Recombinant fragment (around aa1-100) of human p40 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2733RL
    Classification IVD
    Catalogue Number Z2733RL
    Package Inserts
    IFU-p40 ZR303
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.