Gynecological Pathology
    MX007 Mouse Monoclonal

    As one of the cyclin-dependent kinase inhibitors that inhibit cyclin-dependent kinases (CDK) 4 and 6, p16INK4a is encoded by the tumor suppressor gene CDKN2A. It is a specific inhibitor of cdk4/cdk6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16INK4a abnormalities is higher in tumor-derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Cervical squamous cell carcinoma
    Visualization:Cytoplasmic and nuclear
    Isotype:IgG1 /κ
    Immunogen:Recombinant human p16INK4a protein (aa1-156)
    Ordering Information
    Classification IVD
    Catalogue Number Z2016ML
    Classification IVD
    Catalogue Number Z2016ML
    Package Inserts
    IFU-p16INK4a MX007
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.