ZR227 Rabbit Monoclonal

    Oct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. The oct-2 expression can be used as a B-cell lineage and differentiation marker. Germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells show high-level expression of Oct-2. Additionally, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, Hodgkin lymphoma display increased expression of Oct-2. Several studies of Oct-2 expression have shown a low-level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines. In contrast, all mature B-cell lines have high levels of expression. Despite scanty evidence for Oct-2 expression in T cells, it is believed that this factor participates in transcriptional regulation during T-cell activation.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:B-cell lymphoma
    Immunogen:Recombinant human OCT2 protein fragment (around aa 112-297)
    Ordering Information
    Classification IVD
    Catalogue Number Z2708RL
    Classification IVD
    Catalogue Number Z2708RL
    Package Inserts
    IFU-OCT-2 ZR277- 0
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.