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    Nucleophosmin (NPM1)

    Hematopathology
    ZM82 Monospecific Mouse Monoclonal

    Zeta Nucelophosmin Antibody.  Zeta’s recombinant mouse antibody recognizes Nucleophosmin (NPM1), a protein involved in ribosomal assembly and rRNA transport that is predominantly localized in the nucleus of cells in most tissues.  The Nucleophosmin (NPM1) recognizes a 33kDa glycoprotein that is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. The Nucleophosmin (NPM1) phosphoprotein moves between the nucleus and the cytoplasm. Nucleophosmin (NPM1) is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. Mutations in this gene are associated with acute myeloid leukemia. The Nucleophosmin (NPM1) antibody is a useful aid for classification of acute myeloid leukemia.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Tonsil
    Visualization:Nucleoli
    Isotype:IgG1 /κ
    Immunogen:Recombinant human NPM1 protein fragment (aa185-287)
    Ordering Information
    Classification IVD
    Catalogue Number Z2405ML
    Classification IVD
    Catalogue Number Z2405ML
    Package Inserts
    IFU-Nucleophosmin (NPM1) ZM82
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS