preferred clone
Formalin-fixed, paraffin-embedded human colon adenocarcinoma stained with anti-MSH-2 antibody using peroxidase-conjugate and DAB chromogen. Note the absence nuclear staining of tumor cells and the presence of nuclear staining of normal mucosa
Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.
Specifications
Species Reactivity:Humans; others not tested
Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Supplied As:Buffer with protein carrier and preservative
Storage:Store at 2ºC to 8ºC
Control:Colon carcinoma
Visualization:Nuclear
Isotype:IgG
Immunogen:Recombinant fragment (around aa 327-427) of human MSH2 protein
Ordering Information
Package Inserts
SDS