MSH-2

    GI Pathology
    G219-1129 Mouse Monoclonal

    Germline mutations in human mismatch repair genes (hMSH2, hMSH6, hMLH1, hPMS2) account for majority of the hereditary non-polyposis colorectal carcinoma (HPNCC). CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations. These mutations cause a mismatch repair deficiency resulting in a mutator phenotype where the replication errors are not repaired. Microsatellites / simple repetitive sequences are prone to this type of replication errors and instability of these microsatellites correlates with the occurrence of HPNCC. hMSH2 binds to another MutS homolog protein GTBP to form a heterodimeric complex called hMutS beta, which binds to insertion/deletion loops in DNA.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Colon carcinoma
    Visualization:Nuclear
    Isotype:IgG1 /κ
    Immunogen:BALB/C mice were injected with recombinant human MSH2 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2129ML
    Classification IVD
    Catalogue Number Z2129ML
    Package Inserts
    IFU-MSH-2 G219-1129 - IVD
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS