MMP-2

    General & Epithelial Markers
    CA-4001 Mouse Monoclonal

    Zeta MMP-2 Antibody.  Zeta’s monoclonal antibody recognizes MMP-2 (Matrix Metalloproteinase-2), an important sub-type of MMPs that has been found to be upregulated in different oncological conditions especially in breast cancer and chronic myeloid leukaemia (CML).   Additionally, MMP-2 elevated expression is correlated with advanced CRC and aggressive tumor characteristics.

    In cellular remodeling, MMPs are some of the most important enzymes are the proteases that mediate the tumor invasion. Matrix metalloproteinase (MMP) is an ensemble of 26 human zinc dependent metalloproteinases out of which 24 are available in humans.  MMPs are proteolytic enzymes capable of degrading connective tissue components. They have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP-2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids. The MMP-2 antibody reacts with both latent and active MMP-2.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Placenta, bladder, breast, and ovarian carcinoma
    Visualization:Cytoplasmic
    Isotype:IgG1 /κ
    Immunogen:A synthetic peptide derived from near N-terminal of human MMP-2 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2089ML
    Classification IVD
    Catalogue Number Z2089ML
    Package Inserts
    IFU-MMP-2 CA-4001 -IVDL
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS