Breast Pathology
    304-1A5 Mouse Monoclonal

    In normal breast tissue, 304-1A5 labels breast ductal and lobular epithelial cells. In tumor cells, it is reactive with all types of breast adenocarcinoma regardless tumor differentiation and types. Adenocarcinomas from other organs rarely express mammaglobin. Mammaglobin is a breast-associated glycoprotein distantly related to secretoglobin family that includes human uteroglobin and lipophilin. Unlike other secretoglobin family members, mammaglobin mRNA expression is breast specific, which has been shown to be a very sensitive marker of occult breast cancer cells in sentinel lymph nodes and peripheral blood. By paraffin immunohistochemistry, the overall sensitivity of mammaglobin for breast cancers was reported about 80%. When combined with other breast-restricted markers such as GCDFP-15, an overall sensitivity of 84% could be achieved. Mammaglobin can play a contributing role in the identification of primary sites of carcinomas presenting at metastatic sites.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Normal or neoplastic breast tissue
    Isotype:IgG1 /κ
    Immunogen:Recombinant full-length protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2007ML
    Classification IVD
    Catalogue Number Z2007ML
    Package Inserts
    IFU-Mammaglobin 304-1A5
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.