preferred clone
Formalin-fixed, paraffin-embedded human lymph node stained with anti-LMO2 antibody using peroxidase-conjugate and AEC chromogen. Note nuclear staining of germinal center cells
The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. It has a particular function in normal and lymphatic endothelial cells involving the regulation of angiogenesis and lymph-angiogenesis. Immunohistochemical studies have also demonstrated the expression of LMO2 in both normal germinal center B-cells and germinal center-derived B-cell lymphomas, including follicular lymphoma and diffuse large B-cell lymphoma. The use of anti-LMO2 is valuable as a tool in the identification of lymphomas of B-cell origin. LMO2 is useful in differentiating follicular lymphoma (LMO2+) from nodal marginal zone lymphoma (LM02-). It also is positive in Hodgkin s and Burkitt s lymphomas.
Specifications
Species Reactivity:Humans; others not tested
Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Supplied As:Buffer with protein carrier and preservative
Storage:Store at 2ºC to 8ºC
Control:Normal lymph node
Visualization:Nuclear
Isotype:IgG
Immunogen:Recombinant human LMO2 protein fragment (around aa 23-140) (exact sequence is proprietary)
Ordering Information
Package Inserts
SDS