ZR170 Rabbit Monoclonal

    Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess a strong immuno-stimulatory capacity and play a central role in initiating and regulating immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. The human spleen, lymph node, thymus, liver, lung, and heart express Langerin protein.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:skin/Langerhans cell histiocytosis
    Visualization:cell surface/cytoplasm.
    Immunogen:Recombinant fragment (around aa50-250) of human Langerin protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2700RL
    Classification IVD
    Catalogue Number Z2700RL
    Package Inserts
    IFU-Langerin ZR170- 0
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.