Formalin-fixed, paraffin-embedded human Langerhans cell histiocytosis stained with anti-langerin antibody using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining of tumor cells
Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess a strong immuno-stimulatory capacity and play a central role in initiating and regulating immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. The human spleen, lymph node, thymus, liver, lung, and heart express Langerin protein.
Specifications
Species Reactivity:Humans; others not tested
Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Supplied As:Buffer with protein carrier and preservative
Storage:Store at 2ºC to 8ºC
Control:skin/Langerhans cell histiocytosis
Visualization:cell surface/cytoplasm.
Isotype:IgG
Immunogen:Recombinant fragment (around aa50-250) of human Langerin protein
Ordering Information
Package Inserts
IFU-Langerin ZR170- IVD 0
SDS