ZR395 Rabbit Monoclonal

    Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic tissues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95% of lung small cell carcinoma and 91% of lung large cell neuroendocrine carcinoma, compared with 75% and 78% with the combined panel of traditional neuroendocrine markers (synaptophysin, chromogranin, and CD56). INSM1 stains 100% of the atypical carcinoids, typical carcinoids, and paragangliomas, but only 3% of adenocarcinomas and 4% of squamous cell carcinomas. Therefore, INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Neuroendocrine tumor/pancreas
    Immunogen:Recombinant fragment (around aa1-300) corresponding to the N-terminus of human INSM1
    Ordering Information
    Classification IVD
    Catalogue Number Z2751RL
    Classification IVD
    Catalogue Number Z2751RL
    Package Inserts
    IFU-INSM1 ZR395
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.