GI Pathology
    EP286 Rabbit Monoclonal

    Insulin-like growth factor II mRNA binding protein 3 (IMP3) is an oncofetal RNA-binding protein that regulates targets such as insulin-like growth factor-2 and beta-actin. IMP3 plays a major role in early embryogenesis involving the development of the intestine, thymus, pancreas, and kidneys. IMP3 mRNA transcript and protein have been demonstrated in high levels in pancreatic cancer tissues but not in benign lesions of the pancreas, chronic pancreatitis, or normal pancreatic tissues. IMP3 can be used to distinguish between pancreatic ductal adenocarcinoma from chronic sclerosing pancreatitis. IMP3 expression has also been found in a variety of other human cancers including renal cell carcinoma, adenocarcinoma of the uterine cervix, endometrial carcinoma, adenocarcinoma of the esophagus, malignant melanoma, Merkel cell carcinoma, urothelial carcinoma, neuroendocrine carcinoma of the lung, adenocarcinoma of the pancreas, and triple negative breast cancer.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Pancreatic ductal adenocarcinoma
    Immunogen:Recombinant fragment within Human IMP3
    Ordering Information
    Classification IVD
    Catalogue Number Z2284RL
    Classification IVD
    Catalogue Number Z2284RL
    Package Inserts
    IFU-IMP-3 EP286
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.