Preferred Clone
Human breast infiltrating ductal carcinoma stained with anti-Her-2/neu antibody using peroxidase-conjugate and DAB chromogen. Note the strong membrane staining (3+) of carcinoma cells.
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Recognizes a protein of 185kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in various carcinomas, especially the breast and ovary.
Specifications
Species Reactivity:Humans; others not tested
Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Supplied As:Buffer with protein carrier and preservative
Storage:Store at 2ºC to 8ºC
Control:Breast carcinomas
Visualization:Cell membrane
Isotype:IgG
Immunogen:Recombinant protein encoding extracellular domain of human c-erbB2
Ordering Information
Package Inserts
IFU-Her-2/neu ZR218 ASR-0
SDS
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