Hemoglobin A

    Hematopathology
    EPR3608 Rabbit Monoclonal

    Hemoglobin alpha chain belongs to the globin family and is involved in oxygen transport from the lung to the various peripheral tissues. Hemoglobin A is comprised of two alpha chains and two beta chains, whereas hemoglobin A2 is comprised of two alpha chains and two delta chains. Immunohistochemical localization of hemoglobin is excellent as an erythroid marker for the detection of immature, dysplastic, and megaloblastic erythroid cells in myeloproliferative disorders, such as erythroleukemia. In contrast, myeloid cells, lymphoid cells, plasma cells, histiocytes and megakaryocytes are negative for hemoglobin alpha antibody. Anti-hemoglobin alpha, combined with CD34, CD117, CD68, and MPO can be helpful in distinguishing between reactive extramedullary hematopoiesis and that seen in neoplastic myeloid disorders in spleen. Anti-hemoglobin alpha is limited to expression by erythroid precursors in bone marrow, thus is of assistance in calculating percentages of erythroid precursors.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Bone marrow or spleen
    Visualization:Cytoplasmic
    Isotype:IgG
    Immunogen:Residues in human hemoglobin alpha chain
    Ordering Information
    Classification IVD
    Catalogue Number Z2204RL
    Classification IVD
    Catalogue Number Z2204RL
    Package Inserts
    IFU-Hemoglobin A EPR3608
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS