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    H3K27me3

    Neuropathology/Endocrine
    Poly Rabbit Polyclonal

    Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. The N-terminal tail of histone H3 can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. Loss-of-function somatic alterations in different components of the polycomb repressive complex 2 (PRC2) occur in the majority of malignant peripheral nerve sheath tumors (MPNSTs). These highly recurrent and specific inactivation of PRC2 components co-occurred with somatic alterations of CDKN2A and NF1. MPNSTs with PCR2 inactivation through EED or SUZ12 alterations showed consistent complete loss of trimethylation at lysine 27 of histone H3 (H3K27me3) by IHC analysis. Approximately 90% of sporadic and radiation associated MPNSTs and 50% NF1-associated MPNSTs show loss of H3K27me3 expression.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Malignant peripheral nerve sheath tumor (nuclear negative)
    Visualization:Nuclear
    Isotype:IgG
    Immunogen:Synthetic peptide containing the sequence AR (me3K) SAP in which me3K corresponds to trimethyl-lysine at residue 27 of human histone H3
    Ordering Information
    Classification IVD
    Catalogue Number Z2319RL
    Classification IVD
    Catalogue Number Z2319RL
    Package Inserts
    IFU-H3K27me3 Poly
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS