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    Glypican 3

    GI Pathology
    1G12 Mouse Monoclonal

    Glypican‐3 (GPC3) is a member of the glypican family of glycosyl phosphatidylinositol-anchored cell-surface heparan sulfate proteoglycans. The 1G12 monoclonal antibody has been used to assess GPC3 expression in malignant and nonmalignant liver tissue samples by immunohistochemistry in formalin-faxed and paraffin-embedded tissue. Studies have shown that GPC3 is expressed at the protein level in most hepatocellular carcinomas, but it is undetectable in normal liver and benign hepatic lesions, including dysplastic and cirrhotic nodules. In addition, GPC3 is significantly elevated in the serum of a large proportion of patients with hepatocellular carcinoma. Based on these results, it has been proposed that GPC3 could be a useful marker to differentiate between benign and malignant liver diseases.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Hepatocellular carcinoma
    Visualization:Cytoplasmic and membranous
    Isotype:IgG1 /κ
    Immunogen:A fragment containing the last 70 amino acids of the core glypican-3 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2103ML
    Classification IVD
    Catalogue Number Z2103ML
    Package Inserts
    IFU-Glypican 3 1G12
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.