Breast Pathology
    ZR358 Rabbit Monoclonal

    GATA-3 (GATA binding protein 3) is a member of the GATA family of transcription factors. This 50kDa nuclear protein regulates the development and subsequent maintenance of various human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 is involved in luminal cell differentiation in the mammary gland and appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 is associated with the expression of estrogen receptor-alpha (ER) in breast cancer. GATA-3 is a novel marker for bladder cancer. The study demonstrated that GATA-3 stained 67% of urothelial Carcinomas but none of the prostate or renal carcinomas.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Breast or urothelial carcinoma
    Immunogen:Full-length human GATA-3 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2742RL
    Classification IVD
    Catalogue Number Z2742RL
    Package Inserts
    IFU-GATA-3 ZR358
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.