Preferred Clone

Human Hodgkin lymphoma stained with anti-Fascin antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of Hodgkin’s cells.

Fascin

Hematopathology

ZM192 Mouse Monoclonal

Human fascin is a highly conserved actin-bundling protein. Fascin, encoded by the human homolog for sn (hsn) gene, has been localized to microspikes and stress fibers of cultured cells where it is thought to be involved in the formation of microfilament bundles. It is expressed predominantly in dendritic cells. Lymphoid cells, myeloid cells and plasma cells are negative. However, Reed Sternberg cells in Hodgkin’s lymphoma are positive for fascin staining. Epstein-Barr virus may induce expression of fascin in B cells. Clone 55K-2 can be used as an effective marker for Reed Sternberg cells.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Hodgkin's lymphoma or spleen

Visualization:Cytoplasmic

Isotype:IgG2a /κ

Immunogen:Full length recombinant human FSCN1 protein

Ordering Information

USA International

Package Inserts

IFU-Fascin ZM192

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

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SDS