Fascin

    Hematopathology
    55K-2 Mouse Monoclonal

    Human fascin is a highly conserved actin-bundling protein. Fascin, encoded by the human homolog for sn (hsn) gene, has been localized to microspikes and stress fibers of cultured cells where it is thought to be involved in the formation of microfilament bundles. It is expressed predominantly in dendritic cells. Lymphoid cells, myeloid cells and plasma cells are negative. However, Reed Sternberg cells in Hodgkin’s lymphoma are positive for fascin staining. Epstein-Barr virus may induce expression of fascin in B cells. Clone 55K-2 can be used as an effective marker for Reed Sternberg cells.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Hodgkin's lymphoma or spleen
    Visualization:Cytoplasmic
    Isotype:IgG1 /κ
    Immunogen:Fascin purified from HeLa cells
    Ordering Information
    Classification IVD
    Catalogue Number Z2079ML
    Classification IVD
    Catalogue Number Z2079ML
    Package Inserts
    IFU-Fascin 55K-2
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS