Human neuroblastoma stained with anti-Factor XIIIa antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of fibroblasts and macrophages.

Factor XIIIa

Dermatopathology

ZM84 Mouse Monoclonal

It recognizes a protein of 83kDa, which is identified as Factor XIIIa. It has been identified in platelets, megakaryocytes, and fibroblast-like mesenchymal or histiocytic cells in the placenta, uterus, and prostate, monocytes and macrophages and dermal dendritic cells. Anti-factor XIIIa has been found to be useful in differentiating between dermatofibroma (almost all cases are positive), dermatofibrosarcoma protuberans (-/+) and desmoplastic malignant melanoma (-). Anti-factor XIIIa positivity is also seen in capillary hemangioblastoma, hemangioendothelioma, hemangiopericytoma, xanthogranuloma, xanthoma, hepatocellular carcinoma, glomus tumor, and meningioma.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Capillary hemangioma, dermatofibroma, and placenta

Visualization:Cytoplasmic and nuclear

Isotype:IgG2a /κ

Immunogen:Recombinant fragment of human Factor XIIIa protein

Ordering Information

USA International

Package Inserts

IFU-Factor XIIIa ZM84

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

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SDS