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    General & Epithelial Markers
    ZR150 Rabbit Monoclonal

    Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2). It generates a methylation epigenetic mark at lysine 27 residue of histone H3 (H3K27me3) to silence gene expression. EZH2 target genes are involved in a variety of biological processes such as stem cell pluripotency, cell proliferation, and oncogenic transformation. The anti-EZH2 expression has been found in a variety of malignancies including prostate, breast, uterine, gastric, and renal cell cancers in addition to melanoma.1-4 Anti-EZH2 expression has been reported in non-small cell lung cancers and lymphoma. The EZH2 protein is usually not detected in normal breast ductal epithelium. EZH2 is usually expressed in follicular centers, but not in mantle zones, follicular and interfollicular T cells, plasma cells, or NK/T cells. However, its expression can be seen in most B-cell and T-cell lymphomas.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Breast carcinoma
    Immunogen:Synthetic peptide corresponding to the C-terminus of human EZH2 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2692RL
    Classification IVD
    Catalogue Number Z2692RL
    Package Inserts
    IFU-EZH2 ZR150
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.