Breast Pathology
    ZR147 Rabbit Monoclonal

    Estrogen receptor (ER) belongs to the steroid receptor superfamily of nuclear receptors. It is a protein with 553 amino acids. The receptor molecule has three domains, i.e., the central DNA-binding domain, the hormone-binding domain at the C-terminal, and the transcription-activating domain at the N-terminal. ER mediates regulatory functions of female sex steroids, mainly 17 (E2), on growth, differentiation, and function in several target tissues, including the female and male reproductive tract, mammary gland, and skeletal and cardiovascular systems. Studies have shown ER α is present in the nuclei of epithelial cells in normal breast and endometrial tissues and a subset of breast carcinomas. Studies with immunohistochemical assay show that positive steroid hormone status has predicted favorable overall survival, independently of hormonal treatment. Secondly, ER α can be used as a tumor marker, preferentially in combination with an antibody to the progesterone receptor, e.g., in the classification of adenocarcinomas.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Breast carcinoma
    Immunogen:Recombinant fragment (around aa495-595) of human ER alpha protein (exact sequence is proprietary)
    Ordering Information
    Classification ASR
    Catalogue Number Z2691RL-A
    Classification IVD
    Catalogue Number Z2691RL
    Package Inserts
    IFU-ER ZR147 - IVD
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.