This MAb recognizes a protein of 170kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin, and epiregulin. EGFR is overexpressed in breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium tumors. It is predominantly present in squamous cell carcinomas.