preferred clone
Formalin-fixed, paraffin-embedded human squamous cell carcinoma stained with anti-desmoglein-3 monoclonal antibody using peroxidase-conjugate and DAB chromogen. Note membranous staining of tumor cells
Recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3). This MAb is particular to Desmoglein-3 and does not cross-react with other members of the Desmoglein family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered an important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.
Specifications
Species Reactivity:Humans; others not tested
Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Supplied As:Buffer with protein carrier and preservative
Storage:Store at 2ºC to 8ºC
Control:Squamous cell carcinoma
Visualization:Membrane
Isotype:IgG
Immunogen:Recombinant fragment (around aa 379-491) human DSG3 protein
Ordering Information
Package Inserts
SDS