ZR128 Rabbit Monoclonal

    Recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3). This MAb is particular to Desmoglein-3 and does not cross-react with other members of the Desmoglein family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered an important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Squamous cell carcinoma
    Immunogen:Recombinant fragment (around aa 379-491) human DSG3 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2438RL
    Classification IVD
    Catalogue Number Z2438RL
    Package Inserts
    IFU-Desmoglein-3 ZR128
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.