Cytokeratin, Pan

    General & Epithelial Markers
    ZM374 Mouse Monoclonal

    Anti-cytokeratin clone ZM374 is a mixture of anti-cytokeratin antibodies reacting with all 20 subtypes of cytokeratins. Unlike pan-cytokeratin clone AE1/AE3, ZM374 reacts with CK7, CK8, CK18, and CK20. In normal tissues, ZM374 is reactive with most epithelial types, including bile ducts and hepatocytes in the liver, bladder epithelium, breast ducts, bronchial epithelium, endometrium, intestinal epithelium of the stomach, duodenum, ileum, colon, rectum, pancreas, ovarian epithelium, pancreatic acini, pituitary acini, pneumocytes, prostate, thyroid, skin (positive on the basal layer and negative on the superficial layers of squamous epithelium), and apocrine and sweat glands. In tumors, ZM374 is reactive with most carcinomas, including breast, transitional cell (TCC), renal cell (RCC), lung adenocarcinoma, lung small cell, lung squamous cell, endometrial, prostate, ovarian, hepatocellular (HCC), colorectal CA, stomach and thyroid. It is negative in certain normal tissues, including the brain, lymphocytes, and all cells of hematolymphoid origin, muscle, brain, nerves, endothelium, and in certain tumors including most melanomas, sarcomas, lymphomas, primitive neuroectodermal tumors (PNET)/Ewing’s and gastrointestinal stromal tumors (GIST). Positivity has been seen on some dendritic cells in lymph nodes, some endothelia, and some muscle cells.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Squamous cell carcinoma, prostate
    Visualization:Membranous and cytoplasmic
    Isotype:Mouse IgG
    Immunogen:Various human cytokeratin peptide fragments
    Ordering Information
    Classification IVD
    Catalogue Number Z2665ML
    Classification IVD
    Catalogue Number Z2665ML
    Package Inserts
    IFU-Cytokeratin, Pan ZM374
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.