Human pancreatic ductal carcinoma stained with anti-keratin 17 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of tumor cells.
The type I cytokeratin 17 (CK17) shows a peculiar localization in human epithelial appendages including hair follicles, which undergo a growth cycle throughout adult life. Additionally, CK17 is induced, along with CK6 and CK16, early after acute injury to human skin. Predominant expression of CK17and the frequent expression of CK8 and CK19, with little CK6/CK16 and CK1/CK10 expression are the characteristic features of basal cell carcinomas (BCC), suggesting that BCC is differentiated towards undifferentiated follicular epithelia, most probably hair bulge cells.
Specifications
Species Reactivity:Humans; others not tested
Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Supplied As:Buffer with protein carrier and preservative
Storage:Store at 2ºC to 8ºC
Control:Squamous cell carcinoma or skin
Visualization:Cytoplasmic
Isotype:IgG2b /κ
Immunogen:Keratin purified from rat enterocytes
Ordering Information
Package Inserts
SDS