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    Cytokeratin 17

    General & Epithelial Markers
    E3 Mouse Monoclonal

    The type I cytokeratin 17 (CK17) shows a peculiar localization in human epithelial appendages including hair follicles, which undergo a growth cycle throughout adult life. Additionally, CK17 is induced, along with CK6 and CK16, early after acute injury to human skin. Predominant expression of CK17and the frequent expression of CK8 and CK19, with little CK6/CK16 and CK1/CK10 expression are the characteristic features of basal cell carcinomas (BCC), suggesting that BCC is differentiated towards undifferentiated follicular epithelia, most probably hair bulge cells.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Squamous cell carcinoma or skin
    Isotype:IgG2b /κ
    Immunogen:Keratin purified from rat enterocytes
    Ordering Information
    Classification IVD
    Catalogue Number Z2254ML
    Classification IVD
    Catalogue Number Z2254ML
    Package Inserts
    IFU-Cytokeratin 17 E3
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.