Cyclin D1

    Hematopathology
    ZM178 Monospecific Mouse Monoclonal

    Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Mantle cell lymphoma
    Visualization:Nuclear
    Isotype:IgG2a /κ
    Immunogen:Synthetic peptide corresponding to residues within aa 200-295 of Cyclin D1
    Ordering Information
    Classification IVD
    Catalogue Number Z2480ML
    Classification IVD
    Catalogue Number Z2480ML
    Package Inserts
    IFU-Cyclin D1 ZM178
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS