ZR452 Rabbit Monoclonal

    Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a member of the CD28 superfamily and is a negative regulator of T cell-mediated immune responses. CTLA-4 expression is induced on the surface of T cells after CD28 binding and activation. It is constitutively expressed in T-regulatory cells, acting as an immune checkpoint inhibitor and downregulating T-cell activity. CTLA-4 primarily inactivates T-cell activity by competing with the CD28 costimulatory molecule. CD28 and CTLA-4 share the identical ligands of CD80 and CD86 on antigen-presenting cells; thus, CTLA-4 competes with CD28 function in T-cell survival, proliferation, and recruitment. In particular, CTLA-4 down-modulates CD4+ helper T-cell activity and enhances Treg immunosuppressive functions. CTLA-4 has been shown to play a role in human diseases. CTLA-4 acts as a physiological brake on the activated immune system to maintain immune homeostasis. Several suppressive mechanisms for T-cell functions have been attributed to CTLA-4.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Lymph node or tonsil
    Visualization:Secreted and cell surface
    Immunogen:Recombinant fragment of human CTLA-4
    Ordering Information
    Classification IVD
    Catalogue Number Z2808RL
    Classification IVD
    Catalogue Number Z2808RL
    Package Inserts
    IFU-CTLA-4-ZR452- 0
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.