Soft Tissue Pathology
    DCS-31 Mouse Monoclonal

    CDK4 is a major catalytic subunit of mammalian D-type cyclins. The gene for cdk4 is localized to human chromosome 12q13. The cdk4 protein is constitutively expressed throughout the cell cycle. It is the assembly and accumulation of functional cdk4/cyclin D complexes, which is rate limiting for the progression through the G1 phase of the cell cycle. Once the complex is formed, it must be activated by the phosphorylation of threonine 172 on the cdk4 subunit, a reaction mediated by a CDK-activating kinase (CAK). Complex formation and phosphorylation are independently regulated events. The phosphorylation of the cdk4 subunit is subject to the regulation of both stimulatory and inhibitory cytokine signals, thereby allowing cdk4 to function as a mid G1 checkpoint. CDK4 gene is amplified in well-differentiated liposarcoma.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Well-differentiated liposarcoma
    Visualization:Nucleus and cytoplasm
    Immunogen: Full length CDK4 of human origin
    Ordering Information
    Classification IVD
    Catalogue Number Z2226ML
    Classification IVD
    Catalogue Number Z2226ML
    Package Inserts
    IFU-CDK4 DCS-31
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.