ZR118 Rabbit Monoclonal

    CD45 is a family of single-chain transmembrane glycoproteins, consisting of at least four isoforms that share a common large intracellular domain. Their extracellular domains are rod-shaped heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1q31-32. CD45 is exclusively expressed in haematolymphoid cells. Almost all haematolymphoid cells, including precursor cells and mature B- and T-lymphocytes, granulocytes, monocytes/histiocytes and interdigitating reticulum cells and follicular dendritic cells, express CD45. This protein is detected in most haematolymphoid neoplasms, i.e., leukemias and malignant lymphomas. Overall, about 90% of malignant lymphomas are CD45 positive. CD45 is an essential marker in the primary tumor screening panel to identify haematolymphoid differentiation. Loss of CD45 in precursor B-cell neoplasms is a negative prognostic parameter.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Lymph node or tonsil
    Visualization:Cell membrane
    Immunogen:Recombinant full-length human PTPRC protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2681RL
    Classification IVD
    Catalogue Number Z2681RL
    Package Inserts
    IFU-CD45RA ZR118
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.