ZR225 Rabbit Monoclonal

    CD23 (FCE2) is a type II integral membrane glycoprotein expressed on mature B cells, monocytes, eosinophils, platelets, and dendritic cells. CD23 is a low-affinity IgE receptor that mediates IgE-dependent cytotoxicity and phagocytosis by macrophages and eosinophils. CD23 associates as an oligomer where cooperative binding of at least two lectin domains is required for high-affinity IgE binding to CD23. It may play a role in antigen presentation by B cells by interacting with CD40. CD23 is associated with the Fyn tyrosine kinase. The truncated molecule can be secreted, then function as a potent mitogenic growth factor. CD23 is expressed on a subpopulation of peripheral blood cells, B-lymphocytes, and EBV transformed B lymphoblastoid cell lines. CD23 is also detected in neoplastic cells from B cell chronic lymphocytic leukemia cases and some cases on centroblastic/centrocytic lymphoma.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Immunogen:Recombinant fragment (around aa 200-300) of human FCER2/CD23 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2516RL
    Classification IVD
    Catalogue Number Z2516RL
    Package Inserts
    IFU-CD23 ZR225
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.