Human tonsil stained with anti-CD21 antibodyusing peroxidase-conjugate and DAB chromogen. Note the membrane staining of follicular dendritic cells in follicles.

CD21

Hematopathology

ZM75 Monospecific Mouse Monoclonal

Recognizes a protein of 140kDa, which is identified as the complement receptor 2 (CR2) / CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFN alpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Tonsil, lymph node

Visualization:Cell membrane

Isotype:IgG1 /κ

Immunogen:Recombinant human CR2 (CD21) protein fragment (around aa 44-196)

Ordering Information

USA International

Package Inserts

IFU-CD21 ZM75

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

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SDS