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    ZR318 Rabbit Monoclonal

    CD138, also designated syndecan-1, is a member of the syndecan family of four transmembrane spanning proteins capable of binding to heparan sulfate and chondroitin sulfate molecules. The syndecans’ main functions are to control cell growth and differentiation as well as to maintain cell adhesion and cell migration. Under normal conditions CD138 is predominantly expressed on mature plasma cells and early pre-B cells, while other hematolymphoid cells are negative. Various types of epithelial cells are also CD138 positive. Squamous epithelial cells show strong membranous and some cytoplasmic staining, except for the mature superficial squamous epithelial cells which are unstained. Mature mesenchymal and neural tissues are not stained. Among hematolymphoid neoplasms, CD138 is expressed in practically all cases of plasma cell malignancies. Among non-hematolymphoid neoplasms the expression of CD138 is found in various types of carcinoma. In the following, the large majority of cases is CD138 positive: skin squamous cell carcinoma and basal cell carcinoma, colorectal adenocarcinoma, cholangiocarcinoma, transitional cell carcinoma, endometrial adenocarcinoma, ductal and lobular breast carcinoma, hepatocellular carcinoma, renal cell carcinoma, and lung adenocarcinoma. CD138 is a very sensitive and specific marker for identification of plasma cells and plasma cell differentiation within hematolymphoid tissues in benign and neoplastic conditions.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Visualization:Cell membrane/cytoplasmic
    Immunogen:Synthetic peptide corresponding to CD138 residues within aa 200-300 of CD138
    Ordering Information
    Classification IVD
    Catalogue Number Z2622RL
    Classification IVD
    Catalogue Number Z2622RL
    Package Inserts
    IFU-CD138 ZR318
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.