ZM287 Mouse Monoclonal

    Recognizes an integral membrane glycoprotein of 150kDa, identified as CD13 (also known as aminopeptidase-N). The antibody recognizes an extracellular epitope. The CD13 antigen is present on most cells of myeloid origin, including granulocytes, monocytes, mast cells, and GM-progenitor cells. It is also expressed by most AML and CML in myeloid blast crises and in a smaller fraction of lymphoid leukemias. CD13 is absent from normal lymphocytes, platelets, and erythrocytes. CD13 is also present on fibroblasts; endothelial cells, epithelial cells from proximal renal tubules and intestinal brush border, bone marrow stromal cells, osteoclasts, and cells lining bile duct canaliculi. CD13 is identical to aminopeptidase N (APN), a prominent membrane-bound metalloprotease present on the surface of the intestinal brush border and renal tubules. CD13 plays a role in the metabolism of biologically active peptides in phagocytosis and bactericidal/tumoricidal activities. It also serves as a receptor for human coronaviruses (HCV). The lineage-restricted pattern of expression of CD13 within the hemopoietic compartment suggests that it may be essential in myeloid cell differentiation.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Myeloid leukemia
    Isotype:IgG1 /κ
    Immunogen:Recombinant fragment (around aa50-250) of human ANPEP protein (exact sequence is proprietary)
    Ordering Information
    Classification IVD
    Catalogue Number Z2524ML
    Classification IVD
    Catalogue Number Z2524ML
    Package Inserts
    IFU-CD13 ZM287
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.